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Cancer Research Center of Hawai'i

Natural Products and Cancer Biology Program

University of Hawai'i at Manoa
651 ILALO Street, BSB Room 241C 
Honolulu, Hawai'i  96813

Office: (808) 564-5843 Lab: (808) 440-5236

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Our mission is to understand the underlying mechanisms that control cancer cell proliferation and metastasis. We are particularly focused on the role of PEA-15 and the ERK MAP kinase pathway in these aspects of cancer formation and progression.  In collaboration with Chemists in the Natural Products and Cancer Biology program we are developing new drugs to target cancer based on our basic research findings. Currently we are examining the disregulation of cell signalling in neuroblastoma, glioma and breast cancer.

Funding for our research has been provided by The National Institutes of Health, the Department of Defense, the Hawaii Community Foundation and the Friends of the Cancer Research Center. Here you can get acquainted with our work through our publications and statement of research interests.  In addition, take a moment to note who is in the lab and some of our collaborators. Our lab is on the beautiful island of Oahu and you can find directions to us here. Thanks for visiting!

mailE-mail: jramos@crch.hawaii.edu
COS:   http://myprofile.cos.com/jramos
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Read our paper in FASEB J on negative regulation of T cell activation by PEA-15.

lab2010
We welcome Toka and Marci for their Summer research projects in the Meiji program!
Read our paper in PlosOne describing the interaction of FIlamin A with R-Ras during melanoma cell migration. Congratulations to Maisel for winning 3rd place at the ASCB MAC poster session!
Read our paper on learning disabilities of PEA15 knockout mice in BMC Neuroscience. highly accessed Take a pictorial tour of our lab facilities. (pps, web)
Read our review on ERK Regulation here. The 4th most downloaded IJBCB paper of 2009! See new work on PEA-15 and RSK2 listed at NLM's Pubmed. Learn more about PEA-15 at our UCSD-Nature Molecule page.
   

Quote

"The first principle (of scientific integrity) is that you must not fool yourself-and you are the easiest person to fool..."- Richard P. Feynman, The Pleasure of Finding Things Out.

 

Web page created and maintained by Joe W. Ramos

Revised: June 2010 

© 2010, Cancer Research Center of Hawaii. All rights reserved.