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Lecture Notes  

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Advanced Cell Biology (CMB 621):

(text: Molecular Biology of the Cell by Alberts et al.)

MEB 301, 3:30-5:20PM T, Th

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Click the lecture title for the powerpoint presentation with active movies. (recent Explorer or Firefox are best).  

THESE LECTURES MAY BE SIGNIFICANTLY UPDATED JUST BEFORE CLASS!

 

November 9- Signal transduction I (Chapter 15: Intro, Steroids, NO, GPCR-Calcium, cAMP) PDF ; BigPDF

November 16Signal transduction II (Chapter 15: Ras, MAP Kinase) PDF; BigPDF

November 16-   Apoptosis (Chapter 17: Programmed Cell Death section only) PDF ; BigPDF
 
Required reading:
Zimmermann et. al."The Machinery of Cell Death"  pdf
N. Mochizuki, et al.  Nature 411:1065-1068  = "FRET analysis of Ras activation" pdf
 
The following material may also be useful:
A. Lowen.  Bioessays 25:888-896 =Apoptosis Signaling Review
P. H. Krammer. Nature 407:789-795 =Review of Fas activation of apoptosis
My favorite APOPTOSIS MOVIE (a 19MB avi file).  This is from the CD in the MBC 4th edition text.
 
 
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Revised: November 2010 

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