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Hervé CHNEIWEISS MD, PhD
Neuroglial Plasticity Unit (U.752) INSERM 2ter rue d'Alésia,
75014 Paris - France Fax (33-1) 45 80 72 93
E-mail: herve.chneiweiss@broca.inserm.fr |
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Research Overview:
Our approach of astrocyte physiology and glial plasticity led us to focus on the processes involved in the maintenance of an adult phenotype, and their relationship to malignant transformation. The majority of adult primitive cerebral tumors and one third of children ones are of glial origin.
We hypothesize that a nervous tissue pathology initiated by an up-regulation of a few growth factors, such as TGFalpha, drives differentiated cells to dedifferentiate before they accumulate mutations and transform into cancer cells. Cell autonomous factors, including intracellular adaptor molecules such as PEA-15, as well as niche factors are analyzed.
Several groups including our lab characterized from human gliomas tumoral cells with stem cells characteristics such as ability to proliferate in non-adherent conditions and initiate a tumor after intracerebral grafting in an immunodeficient animal, from adult and pediatric tumors. We are currently analyzing their proteomic profile to reveal new biomarkers, their GPCRs expression to screen for new anti-tumoral drugs and their mechanisms of chemoresistance to existing therapeutics and novel EGFR-targeted drugs.
Publications in PUBMED
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