J.W. Ramos, D.A. Townsend, D. Piarulli, S. Kolata, K. Light, G. Hale, and L.D. Matzel.  Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities. BMC Neuroscience, 10:134 (2009).   PDF

M. Gudur Valmiki and J.W. Ramos.  Death Effector Domain-Containing Proteins. CMLS, 66(5):814-30 (2009).  PDF

  J.W. Ramos.  Pea15a. UCSD-Nature Molecule Pages.(doi:10.1038/mp.a002536.01) (2008).

  J.W. Ramos.  The Regulation of Extracellular Signal-Regulated Kinase (ERK) in Mammalian Cells. IJBCB, 40(12):2707-2719 (2008).  PDF -the 4th most downloaded IJBCB paper of 2009

  S. Pastorino and J.W. Ramos.  Glioma: Challenges and new insights in the development of effective therapies. Hawaii Medical Journal. 67:20-23 (2008).  PDF

 H. Vaidyanathan, J. Opoku-Ansah, S. Pastorino, H. Renganathan, M.L. Matter, and J.W. Ramos.  ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. PNAS. 104(50): 19837-19842 (2007).  PDF

  F. Renault-Mihara, F. Beuvon, X. Iturrioz, B. Canton, S. De Bouard, N. Léonard, S. Mouhamad, A. Sharif, J.W. Ramos, M-P. Junier, and H Chneiweiss.   PEA-15 Expression Inhibits Astrocyte Migration by a PKC Delta-Dependent Mechanism.   Mol. Biol. Cell, 17(12):5141-52 (2006). PDF

   M.L. Matter and J.W. Ramos.   Expression cloning of signaling proteins regulated by cell adhesion.  Methods in Molecular Biology, vol. 341: Cell-Cell Interactions: Methods and Protocols.  Sean P. Colgan ed., Humana Press Inc, Totowa, NJ. (2006).

  H. Renganathan, H. Vaidyanathan, A. Knapinska and J.W. Ramos.  Phosphorylation of PEA-15 Switches its Binding Specificity from ERK MAP kinase to FADD.  Biochem J. 390(3):729-735 (2005).  PDF

   J.W. Ramos.  PEA-15 Phosphoprotein: a potential cancer drug target. Hawaii Medical Journal. 64:77-79 (2005).  
PDF

  R. Sur and J.W. Ramos.  Vanishin is a novel ubiquitinylated death effector domain protein that blocks ERK activation.  Biochem J. 387(2):315-324 (2005). PDF

F-L. Chou, J. M. Hill, J-C. Hsieh, J. Pouyssegur, A. Brunet, A. Glading, F. Überall, J.W. Ramos, M.H. Werner, and M.H. Ginsberg.   PEA-15 binding to ERK1/2 MAP kinases is required for its modulation of integrin activation.  J. Biol. Chem.  278(52):52587-52597 (2003).  PDF

H. Vaidyanathan and J.W. Ramos.   Rsk2 activity is regulated by its association with PEA-15.  J. Biol. Chem.  278(34):32367-32372 (2003).  PDF

  J.M. Hill, H. Vaidyanathan, J.W. Ramos, M.H. Ginsberg and M.H. Werner.  Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain.  EMBO J  21(23):6494-6504 (2002).  PDF

  J.W. Ramos and M.H. Ginsberg.    Expression cloning strategies for the identification of adhesion molecules.  Methods in Cell-matrix adhesion.  Josephine Adams ed., Academic Press (2002).

  M.L. Matter, M.H. Ginsberg, and J.W. Ramos.  Identification of cell signaling molecules by expression cloning.  Science's STKE, 2001 (103), pl9. (doi: 10.1126/stke.2001.103.pl9) (2001).

  J.W. Ramos*, E. Formstecher*, M. Fauquet, D.A. Calderwood, J-C. Hsieh, B. Canton, X-T. Nguyen, J-V. Barnier, J. Camonis,  M.H. Ginsberg, and H. Chneiweiss.   PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.  Developmental Cell 1:239-250 (2001).  *Co-first authors.  PDF

  Y. Zhang, O. Redina, Y.M. Altshuller, M. Yamazaki, J. Ramos, H. Chneiweiss, Y. Kanaho, M.A. Frohman.  Regulation of PLD1 and PLD2 expression levels by PEA-15, a novel PLD-interacting protein. J.Biol.Chem. 275:35224-35232 (2000).  PDF

  J.W. Ramos, P.E. Hughes, M.W. Renshaw, H. Chneiweiss, and M.H. Ginsberg.  The Death Effector Domain Protein, PEA-15, potentiates Ras activation of ERK by an adhesion independent mechanism.  Mol.Biol.Cell. 11:2863-72(2000).  PDF

  C.A. Fenczik, J.W. Ramos, and M.H. Ginsberg.  Expression cloning of proteins that modify integrin activation.  Signaling Through Cell Adhesion Molecules.  Jun-Lin Guan ed., CRC Press, pgs. 235-243 (1999).

  J.W. Ramos, T.J. Kojima, P.E. Hughes, C.A. Fenczik, and M.H. Ginsberg.  The Death Effector Domain of PEA-15 is involved in its regulation of integrin activation. J. Biol. Chem. 273:33897-33900 (1998).  PDF

  C.A. Fenczik, T. Sethi, J.W. Ramos, P.E. Hughes, and M.H. Ginsberg.  Complementation of dominant suppression implicates CD98 in integrin activation.  Nature 390:81-85 (1997).  PDF

  J.W. Ramos, C.A. Whittaker, and D.W. DeSimone.  Integrin-dependent adhesive activity is spatially controlled by inductive signals at gastrulation.  Development  122:2873-2883 (1996).  PDF

  J.W. Ramos and D.W. DeSimone.  Xenopus embryonic cell adhesion to fibronectin: position-specific activation of RGD/synergy-site-dependent migratory behavior at gastrulation. J. Cell Biology 134:227-240 (1996).  PDF

  D. Alfandari,  J. Ramos, L. Clavilier, D.W. DeSimone, and T. Darribere.  The RGD-dependent and Hep II binding domains of fibronectin govern the adhesive behavior of amphibian embryonic cells.  Mech. of Development.  56:83-92 (1996).  PDF

  K. Danker, H. Hacke, J. Ramos, D.W. DeSimone, and D. Wedlich.  V+ Fibronectin expression and localization prior to gastrulation in Xenopus laevis embryos. Mech. of Development 44:155-165 (1993).

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