Richard
Allsopp, Ph.D. Assistant
Professor (Researcher), Institute for Biogenesis Resesarch, John
A. Burns School of Medicine
Ph.D. (Biochemistry), McMaster
University
My
interests are in understanding the regulation of telomerase
expression in both normal and cancer cells. My lab investigates
the role of specific candidate regulators of the key regulatory
component of telomerase, TERT, in the regulation of telomerase
activity in mice. In addition, my lab is investigating the
potential role of telomerase suppression in fetal growth restriction
in humans. We are also interested in assessing the relative
efficiency of cloning mice via nuclear transfer technology
developed at the IBR using different types of stem cells.
Selected
Publications
Allsopp
RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT over-expression on the long-term transplantation
capacity of hematopoietic stem cells. Nat Med 9:369-71, 2003.
Allsopp
RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase
is required to slow telomere shortening and extend replicative
lifespan of HSCs during serial transplantation. Blood 102:517-20,
2003.
Allsopp
RC, Cheshier S, Weissman IL. Telomerase activation and rejuvenation
of telomere length in stimulated T cells derived from serially
transplanted hematopoietic stem cells. J Exp Med 196:1427-33,
2002.
Allsopp
RC, Weissman IL. Replicative senescence of hematopoietic stem
cells during serial transplantation: Does telomere shortening
play a role? Oncogene 21:3270-3, 2002.
Vaziri
H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp
PM. Evidence for a mitotic clock in human hematopoietic stem
cells: Loss of telomeric DNA with age. Proc Natl Acad Sci USA
91:9857-60, 1994.
