Marc Goodman, Ph.D.

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Cancer Research Center of Hawaii

Marc T. Goodman, Ph.D., M.P.H.
Professor (Researcher), Cancer Research Center of Hawaii;
Adjunct Associate Professor of Public Health;
Graduate Faculty in the Interdisciplinary Biomedical Sciences Graduate Program
MPH (Epidemiology), University of California at Los Angeles;
Ph.D. (Epidemiology), Yale University
marc@crch.hawaii.edu

Publication list via PubMed

General Research Interests
My research interests are broad but concentrate principally on cancer prevention and the identification of molecular mechanisms in carcinogenesis. Ongoing work focuses on the epidemiology and genetics of ovarian cancer, the molecular basis through which endocrine-, nutrition-, and immune-related factors increase postmenopausal breast cancer risk, the natural history of HPV infection in the cervix and anus, and the use of cancer registry-based biological repositories to explore phenotypic and prognostic markers of malignancy.

The biological interplay between hormones, diet, and metabolism on the risk of cancer in women has been a longstanding interest of our research team, including etiologic investigations of breast, ovarian and uterine cancers, and a dietary intervention study of breast cancer. The ongoing Collaborative Study of Ovarian Cancer (R01CA58598) began in1993 to determine whether the substantial ethnic differences in ovarian cancer incidence reflect ethnic variation in known risk factors, such as pregnancy history or oral contraceptive pill use; or whether differences in dietary exposure to fat or lactose, or genetic susceptibility are also important determinants of this disease. The second cycle of this grant built on our previous work to examine the hypothesis that selected polymorphisms in genes associated with steroid hormone metabolism, oxidative stress, and immunity are related to the risk of ovarian cancer. We have now established a substantial resource that has been used to publish articles on a variety of significant issues associated with epithelial ovarian cancer risk.

Breast cancer is a heterogeneous disease with a number of biological subtypes that may reflect differences in genetic or environmental exposures. As part of a program project grant led by Laurence Kolonel, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study (P01CA33619), we are testing various hypotheses regarding the association of urinary isoflavones/lignans, plasma antioxidants, serum hormones, urinary hydroxyestrogens, and plasma IGF with the etiology of postmenopausal breast cancer.

Prompted by the availability of a new HPV DNA amplifying technique, polymerase chain reaction, we initiated our first case-control study of risk factors for pre-malignant changes in cervical epithelium in the early 1990s, with a special emphasis on diet. Since that time, we have established multiethnic cohorts of women and men for long-term follow-up to identify factors that influence the persistence of human papillomavirus (HPV) infection of the cervix, penis, and anus. The ongoing Cohort Study of Diet and Duration of Cervical HPV Infection (R01CA77318) began in 1998 to examine nutrition- and immune-related hypotheses concerning HPV persistence among a multiethnic cohort of infected women. Our data suggest several viral and non-viral determinants of cervical HPV acquisition, such as serum carotenoids and co-existing cervical HPV infections. Long-term follow-up will help us to better define the influence of diet and nutrition on the persistence of HPV infection, and will allow us to prospectively investigate several novel indices of cervical inflammation as co-factors in viral persistence, including patterns of local cytokine expression.

Our group administers the Hawaii Tumor Registry (N01PC35137), which has been part of the Surveillance Epidemiology and End Results (SEER) Program of the National Cancer Institute since its inception in 1973. The registry provides complete cancer reporting for the entire state and serves as a resource for nearly all epidemiologic research activity and cancer control activities in Hawaii. This racially diverse database has been invaluable in demonstrating ethnic variations in cancer incidence and survival. Furthermore, we have expanded our registry activities to gather formalin-fixed, paraffin-embedded tissue from cancer patients on a population basis. This repository provides a unique resource for testing new molecular classification schemes for cancer, validating new biologic markers of malignancy, prognosis and progression, assessing therapeutic targets, and measuring allele frequencies of cancer-associated genetic polymorphisms or germline mutations in representative samples.

Active Grants
M.T. Goodman, Principal Investigator
R01 CA 077318
"Cohort Study of Diet and Duration of Human Papillomavirus Infection"
April 1, 2005-March 31, 2010

M.T. Goodman, Principal Investigator
N01 PC 035137
"Surveillance, Epidemiology, End-Results"
August 1, 2003-July 31, 2010

M.T. Goodman, Principal Investigator
N01 PC 035137(S)
"POPBLOCKS"
August 1, 2003-July 31, 2010

C.W. Vogel, Principal Investigator
M.T. Goodman, Tumor Registry Core Leader
U56 CA 096254
"University of Guam/Cancer Research Center of Hawai‘i Partnership"
April 1, 2003-March 31, 2009

M.T. Goodman, Principal Investigator
R01 CA 058598
"Collaborative Study of Ovarian Cancer in Two Risk Groups"
April 12, 2001-March 31, 2009

L. Kolonel, Principal Investigator
M.T. Goodman, Project Leader, Core Leader, Co-Investigator
P01 CA 033619
"Epidemiologic Studies of Diet and Cancer in Hawai‘i"
July 1, 2000-June 30, 2009

Selected Publications
Goodman MT, Shvetsov YB, McDuffie K, Wilkens LR, Zhu X, Thompson PJ, Ning L, Killeen J, Kamemoto L, Hernandez BY. Prevalence, acquisition, and clearance of cervical human papillomavirus infection among women with normal cytology: Hawaii Human Papillomavirus Cohort Study. Cancer Research 2008;68:8813-24.

Goodman MT, Shvetsov YB, McDuffie K, Wilkens LR, Zhu X, Ning L, Killeen J, Kamemoto L, Hernandez BY. Acquisition of anal human papillomavirus infection among women: the Hawaii HPV Cohort Study. Journal of Infectious Disease 2008;197:957-966.

Hernandez BY, Wilkens LR, Zhu X, McDuffie K, Thompson P, Shvetsov YB, Ning L, Goodman MT. Circumcision and Human Papillomavirus Infection in Men: A Site-Specific Comparison. Journal of Infectious Disease 2008;197:787-794.

Goodman MT, Shvetsov YB, McDuffie K, Wilkens LR, Zhu X, Franke AA, Bertram CC, Kessel B, Bernice M, Sunoo C, Ning L, Easa D, Killeen J, Kamemoto L, Hernandez BY. Hawaii multiethnic cohort study of serum micronutrient concentrations and clearance of incident oncogenic human papillomavirus inection. Cancer Research 2007;67:5987-96.

Lurie G, Wilkens LR, Thompson P, McDuffie KE, Carney ME, Terada KY, Goodman MT. Vitamin D receptor gene polymorphisms and epithelial ovarian cancer risk. Cancer Epidemiology Biomarkers and Prevention 2007;16:2566-71.

Lurie G, Thompson P, McDuffie K, Carney ME, Terada KY, Goodman MT. The association of estrogen and progestin potency of oral contraceptives with ovarian carcinoma risk. Obstetrics and Gynecology 2007;109:597-607.

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